{"id":7707,"date":"2019-08-02T15:48:08","date_gmt":"2019-08-02T19:48:08","guid":{"rendered":"https:\/\/childrenshearing.org\/?page_id=7707"},"modified":"2019-08-05T11:20:34","modified_gmt":"2019-08-05T15:20:34","slug":"implications-for-intervention","status":"publish","type":"page","link":"https:\/\/childrenshearing.org\/implications-for-intervention\/","title":{"rendered":"A study of immunologic mechanisms in Sudden Sensorineural Hearing Loss and Autoimmune Inner Ear Disease in Children: Implications for Intervention"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_widget_sidebar sidebar_id=&#8221;professionals-sidebar&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div class=\"shortcode-wrapper shortcode-title clearfix\"><h1 style=\"color:#004f9d!important;border-color:#004f9d\" class=\"\">A study of immunologic mechanisms in Sudden Sensorineural Hearing Loss and Autoimmune Inner Ear Disease in Children: Implications for Intervention<\/h1><\/div><div class=\"shortcode-wrapper shortcode-spacer clearfix\"><div class=\"spacer\"><\/div><\/div>[vc_column_text]<strong><u>Organization:<\/u><\/strong> The Feinstein Institute for Medical Research in conjunction with the Apelian Cochlear Implant Center at Northwell Health-Zucker School of Medicine at Hofstra\/Northwell.[\/vc_column_text][vc_column_text]<strong><u>Project \u00a0Rationale<\/u><\/strong><u>:<\/u> Immune mediated hearing loss is comprised of Sudden sensorineural hearing loss (SSNHL) and Autoimmune Inner Ear Disease (AIED).\u00a0 Both of these diseases respond to corticosteroids in approximately 70% of adult patients, however no alternative treatment options have been identified for those that do not. These diseases have been observed and treated in children, but are even more underappreciated than their adult counterparts.\u00a0 There is no data available as to the incidence or corticosteroid responsiveness of either AIED or SSNHL in the pediatric population.\u00a0 Although our clinical observations suggest they have reduced corticosteroid-responsiveness, this has not been rigorously studied.\u00a0 The proposed project will both define the incidence in this population and characterize the immunologic mediators in the peripheral blood of these patients.\u00a0 Whole exome sequencing may elucidate novel genetic markers that regulate immune mediated hearing loss.\u00a0 By comparing the blood of the child to the unaffected parent, we should be able to identify novel genetic targets if immune mediated hearing loss has a genetic risk factor.[\/vc_column_text][vc_single_image image=&#8221;7717&#8243; img_size=&#8221;200w&#8221;]<div class=\"shortcode-wrapper shortcode-spacer clearfix\"><div class=\"spacer\"><\/div><\/div>[\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_widget_sidebar sidebar_id=&#8221;professionals-sidebar&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Organization: The Feinstein Institute for Medical Research in conjunction with the Apelian Cochlear Implant Center at Northwell Health-Zucker School of&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - 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